Set in London between 1900 and 1925, the story follows Louisa Leyton/Trotter, the eponymous "Duchess", who works her way up from servant to renowned cook to proprietress of the upper-class Bentinck Hotel in Duke Street, St. James's.
Change is in the air at the hotel and in the lives of its many residents. An American writer, Sophie Applegate, would like to pen a book about Louisa's life, successes and failures. Louise isn't all that keen on the venture but eventually rises to the occasion and opens up about her past.